News

Another setback, yet another reason to redouble our efforts

By | In the News, UCI MIND

Contributed by Joshua Grill, PhD, Director of UCI MIND Late Thursday evening, Esai publicly announced a decision to halt a Phase 3 clinical trial of a candidate treatment for Alzheimer’s disease, elenebecestat. The decision was made based on a recommendation by the study’s Data Safety Monitoring Board, which determined that the safety risks of the drug no longer justified continuing the study. Elenebecestat is a BACE (beta-site of the amyloid precursor protein cleavage enzyme) inhibitor that joins several other BACE inhibitors previously determined to lack adequate safety for patient use. The field will grapple with this news and learn how…

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How can “smart” technology be used to detect cognitive problems?

By | Commentary, Community Events, UCI MIND

How can “smart” technology be used to detect cognitive problems? October 25th Research Conference #SpeakerSpotlight: Dr. Rhoda Au is a Professor of Anatomy & Neurobiology, Neurology and Epidemiology at Boston University and has served as an investigator on the Framingham Heart Study since 1990, conducting research related to cognitive aging and dementia. Dr. Au’s research focuses on a how “bigdata” analytics can better inform our understanding of Alzheimer’s disease. In the session, “Detection in the Digital Era,” Dr. Au will discuss how innovative technology can be used to track cognitive performance in older adults. Attendees will learn how digital technologies…

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How are brain scans improving our understanding of Alzheimer’s disease?

By | Commentary, Community Events, UCI MIND

How are brain scans improving our understanding of Alzheimer’s disease? October 25th Research Conference #SpeakerSpotlight: Dr. William Jagust is a Professor of Public Health and Neuroscience at UC Berkeley and heads the national Alzheimer’s Disease Neuroimaging Initiative’s (ADNI) Core Laboratory for PET imaging. His laboratory was the first to describe Alzheimer’s-related hippocampal atrophy quantified with MRI and has continued to pioneer approaches using brain imaging to improve understanding of aging and dementia. In the session “Brain Scans and Biomarkers,” Dr. Jagust will describe how brain imaging has helped advance the field and discuss the strengths and challenges of brain scan…

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What have researchers learned from brain donations?

By | Community Events, UCI MIND

Tune in this Friday, September 6 @ 9AM for the next episode of our monthly Facebook LIVE series, “What have researchers learned from brain donations?” This month, we’re joined by Edwin Monuki, MD, PhD. Dr. Monuki is a neuropathologist, meaning he specializes in the diagnosis of brain diseases by examining post-mortem tissue. His research aims to improve understanding of an understudied brain tissue known as the choroid plexus in an effort to develop potential new therapies for brain diseases, such as Alzheimer’s. Dr. Monuki earned his medical and doctoral degrees from UC San Diego and currently serves as Professor and…

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How are donated human brains used to study Alzheimer’s disease?

By | Commentary, Community Events, UCI MIND

How are donated human brains used to study Alzheimer’s disease? October 25th Research Conference #SpeakerSpotlight: Dr. Julie Schneider is a board-certified Geriatric Neurologist and Neuropathologist, Professor of Pathology and Neurological Sciences at Rush University, and Associate Director of the Rush Alzheimer’s Disease Center. Dr. Schneider’s research focuses on linking pathology with risk factors and brain imaging to improve understanding of cognitive aging and dementia. Brain donation has been an invaluable resource for researchers to better understand the causes of and treatment options for Alzheimer’s disease and related dementias. In the session, “Gifted Brains Yield Priceless Gains,” Dr. Schneider will discuss…

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Summer 2019 MIND Matters Newsletter

By | Commentary, Community Events, In the News, UCI MIND

In this issue of MIND Matters: UCI MIND Scientists Discover Exercise Can Reprogram Genes Welcome, New Faculty & Staff New FDA Black Box Warning for Insomnia Medications Announcing the 10th Annual UCI MIND Gala Honorees… And more! Download Newsletter >   Upcoming Events:   Facebook LIVE Q&A Series: “What have researchers learned from brain donations?” Friday, September 6  |  9:00-9:30 am |  UCI MIND Facebook Page Follow @UCIrvineMIND to receive notifications when we go LIVE Live online Q&A with Edwin Monuki, MD, PhD, Professor and Warren L. Bostick Chair of Pathology in the UCI School of Medicine.  Attend the video live on our Facebook page or view archived…

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How is Alzheimer’s disease diagnosed?

By | Community Events, UCI MIND

How is Alzheimer’s disease diagnosed? October 25th Research Conference #SpeakerSpotlight: Dr. David Sultzer is a board-certified Geriatric Psychiatrist and Professor of Psychiatry & Human Behavior at UCI School of Medicine. After more than 20 years at UCLA and the West Los Angeles VA Hospital, Dr. Sultzer recently joined the team at UCI MIND and leads its clinical research operations, including clinical trials for new treatments. He is internationally recognized for his research activities to better understand the phenomenology, pathophysiology, and treatment of Alzheimer’s disease. In the session “Advances in Clinical Diagnosis,” Dr. Sultzer will explain how doctors arrive at a…

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