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Biogen terminates phase 4 efficacy study of aducanumab

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Biogen, the maker of aducanumab has announced that it will terminate the Phase 4 trial required by the FDA for aducanumab, the monoclonal antibody against beta amyloid that received accelerated approval in 2021. The company is also halting production of the compound and relinquishing ownership rights to the original developer, Neurimmune. Accelerated approval was based on the demonstration in multiple studies that treatment with aducanumab could lower brain amyloid in people with Alzheimer’s disease. But two Phase 3 trials gave contrasting results about aducanumab’s efficacy, preventing the FDA from granting full clinical approval for the medication. A requirement of accelerated…

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New Alzheimer’s drugs bring hope. But not equally for all patients.

By Carousel Slider, In the News, UCI MIND

The medications have not been widely tested in Black people with the disease, underscoring stark — and persistent — disparities ABINGTON, Pa. — Wrapped in a purple blanket, Robert Williford settles into a quiet corner of a bustling neurology clinic, an IV line delivering a colorless liquid into his left arm. The 67-year-old, who has early Alzheimer’s disease, is getting his initial dose of Leqembi. The drug is the first to clearly slow the fatal neurodegenerative ailment that afflicts 6.7 million older Americans, though the benefits may be modest. The retired social worker, one of the first African Americans to receive the…

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Sound waves get Alzheimer’s drug past brain barrier, small study shows

By Carousel Slider, In the News, UCI MIND

In the first study of its kind in humans, researchers have discovered that it is safe to use sound waves fired into specific areas of the brain to open a protective barrier and clear the way for Alzheimer’s medications. The study, reported in the New England Journal of Medicine, involved just three patients, but it raises hope about the long-term potential of the treatment strategy known as focused ultrasound. […] Joshua Grill, professor of psychiatry and human behavior at University of California at Irvine, called the study “biologically very exciting,” adding that the research may help scientists understand why some…

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Strategies and habits for a longer, healthier life

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TAMPA (BLOOM) – Join us as we explore strategies—from mindful living to emerging technologies—and discover how every choice can lead to a longer and healthier life. Welcome to the science of aging, where the pursuit of health and happiness is the entire goal. […] Lifestyle Habits for Longevity Avoiding Harmful Substances In the pursuit of a longer, healthier life, steering clear of harmful substances is an obvious decision. Dr. Claudia Kawas, a distinguished neurologist at the University of California, Irvine, sounds the alarm on two major culprits: smoking and excessive alcohol consumption. Smoking, known for its detrimental effects on respiratory health,…

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Celebrating What’s Right With Aging: Inside the Minds of Super Agers

By Carousel Slider, In the News, UCI MIND

Some people in their 80s and 90s show shockingly little decline in their brainpower. Scientists are beginning to understand what makes them different and how the rest of us might benefit You can find Vernon Smith hard at work at his computer by 7:30 each morning, cranking out 10 solid hours of writing and researching every day. His job is incredibly demanding — he is currently on the faculty of both the business and law schools at Chapman University. But the hard work pays off: Smith’s research is consistently ranked as the most-cited work produced at the school — a…

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Researchers testing out drug for Alzheimer’s prevention

By Carousel Slider, In the News, UCI MIND

More than 6 million Americans have Alzheimer’s disease, and the CDC expects that number to double in the next three decades. The first drug fully approved by the FDA for Alzheimer’s has been on the market for 10 months. Now, researchers are looking at testing it to prevent Alzheimer’s. A shot that could one day prevent Alzheimer’s disease — that’s the potential future for lecanemab, or Leqembi. […] Researchers are studying to see if the drug can prevent the disease. “We hope [to] make breakthroughs in discoveries that change our ability to help people in their lives, prevent them from getting…

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More good news from CMS

By Carousel Slider, In the News, UCI MIND

On Friday October 13, 2023, the Centers for Medicare and Medicaid Services (CMS) announced a formal change to their coverage policy for amyloid PET imaging. Previously, with limited exceptions, patients were required to be enrolled in a clinical study known as “Coverage with Evidence Determination” for the scan to be reimbursed. Now, that requirement has been removed and the door has been opened for more patients to get the scan and result in savings of thousands of dollars for patients and their families. In fact, patients may have the opportunity to receive multiple covered scans as part of their routine care…

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How Old is Too Old to Govern?

By Carousel Slider, In the News, UCI MIND

Most Americans favor an age limit for the president and other politicians. But some ethicists and scientists argue that’s ageist and scientifically unsound. Barring a considerable shift in the political winds, the next US president will be either 82 or 78 years old on Inauguration Day. Meanwhile, Senate Minority Leader Mitch McConnell, who twice froze in front of cameras and was unable to speak for several agonizing moments, is 81. His Democratic counterpart, Majority Leader Chuck Schumer, is a comparative spring chicken at 72. Senator Dianne Feinstein died last month at age 90, after months of frequent absences from the chamber…

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