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Is Preclinical Alzheimer’s Disease a Business Product?

By Carousel Slider, Commentary, UCI MIND

The LA Times recently published a fairly negative appraisal of the construct of preclinical Alzheimer’s disease (AD). The article described the recent effort by an international committee to update diagnostic criteria that date back to 1984, updated in 2011 and again in 2018. The most recent updates have been presented at meetings and published online and have indeed been the source of debate and disagreement in the field. But the LA Times article goes quite a bit further, essentially asking if one particular aspect of the criteria—the definition of preclinical AD—exists mainly to benefit pharmaceutical and medical testing companies. So…

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Biogen terminates phase 4 efficacy study of aducanumab

By Carousel Slider, In the News, UCI MIND

Biogen, the maker of aducanumab has announced that it will terminate the Phase 4 trial required by the FDA for aducanumab, the monoclonal antibody against beta amyloid that received accelerated approval in 2021. The company is also halting production of the compound and relinquishing ownership rights to the original developer, Neurimmune. Accelerated approval was based on the demonstration in multiple studies that treatment with aducanumab could lower brain amyloid in people with Alzheimer’s disease. But two Phase 3 trials gave contrasting results about aducanumab’s efficacy, preventing the FDA from granting full clinical approval for the medication. A requirement of accelerated…

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New Alzheimer’s drugs bring hope. But not equally for all patients.

By Carousel Slider, In the News, UCI MIND

The medications have not been widely tested in Black people with the disease, underscoring stark — and persistent — disparities ABINGTON, Pa. — Wrapped in a purple blanket, Robert Williford settles into a quiet corner of a bustling neurology clinic, an IV line delivering a colorless liquid into his left arm. The 67-year-old, who has early Alzheimer’s disease, is getting his initial dose of Leqembi. The drug is the first to clearly slow the fatal neurodegenerative ailment that afflicts 6.7 million older Americans, though the benefits may be modest. The retired social worker, one of the first African Americans to receive the…

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Studies on negative impacts of sleep deprivation continue to sleep on Blacks

By Carousel Slider, Commentary, UCI MIND

Black people know intrinsically about the myriad of life areas negatively impacted by the fact that the myth of white supremacy is baked into the foundations of all American institutions. But one area that doesn’t get enough attention is how racism robs Blacks of one of nature’s most powerful healing agents – sleep. Blacks have disproportionately higher rates of sleep disorders (sleep apnea, insomnia, more light and less deep sleep, delayed onset, more daytime sleepiness, and shorter sleep duration) compared to any other racial and ethnic groups in the U.S. These disparities are compounded by the fact that they contribute…

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Sound waves get Alzheimer’s drug past brain barrier, small study shows

By Carousel Slider, In the News, UCI MIND

In the first study of its kind in humans, researchers have discovered that it is safe to use sound waves fired into specific areas of the brain to open a protective barrier and clear the way for Alzheimer’s medications. The study, reported in the New England Journal of Medicine, involved just three patients, but it raises hope about the long-term potential of the treatment strategy known as focused ultrasound. […] Joshua Grill, professor of psychiatry and human behavior at University of California at Irvine, called the study “biologically very exciting,” adding that the research may help scientists understand why some…

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Strategies and habits for a longer, healthier life

By Carousel Slider, In the News, UCI MIND

TAMPA (BLOOM) – Join us as we explore strategies—from mindful living to emerging technologies—and discover how every choice can lead to a longer and healthier life. Welcome to the science of aging, where the pursuit of health and happiness is the entire goal. […] Lifestyle Habits for Longevity Avoiding Harmful Substances In the pursuit of a longer, healthier life, steering clear of harmful substances is an obvious decision. Dr. Claudia Kawas, a distinguished neurologist at the University of California, Irvine, sounds the alarm on two major culprits: smoking and excessive alcohol consumption. Smoking, known for its detrimental effects on respiratory health,…

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UCI MIND director’s research on differences in trial eligibility by race and ethnicity is featured in Neurology Today

By Carousel Slider, UCI MIND

UCI MIND Director, Dr. Joshua Grill, is quoted in Neurology Today for his work with colleagues at USC, Massachusetts General Hospital, Brigham and Women’s Hospital, and Eisai on racial and ethnic disparities in eligibility for Alzheimer’s disease clinical trials. To read the article, click here.

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Celebrating What’s Right With Aging: Inside the Minds of Super Agers

By Carousel Slider, In the News, UCI MIND

Some people in their 80s and 90s show shockingly little decline in their brainpower. Scientists are beginning to understand what makes them different and how the rest of us might benefit You can find Vernon Smith hard at work at his computer by 7:30 each morning, cranking out 10 solid hours of writing and researching every day. His job is incredibly demanding — he is currently on the faculty of both the business and law schools at Chapman University. But the hard work pays off: Smith’s research is consistently ranked as the most-cited work produced at the school — a…

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