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UCI Spearheads $109M Down Syndrome, Alzheimer’s Study

By Carousel Slider, Commentary, In the News, UCI MIND

The University of California, Irvine is undertaking a five-year, multi-million dollar project to expand research on Alzheimer’s disease in people with Down syndrome. The National Institute of Health awarded a $109 million grant to the Alzheimer’s Biomarkers Consortium-Down Syndrome in late October. The international team, led by UCI principal investigators Elizabeth Head and Mark Mapstone, aims to identify biomarkers that indicate the progression of Alzheimer’s disease in adults with Down syndrome. Subscribers to the Orange County Business Journal can read more here >          

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Governor’s Task Force on Alzheimer’s Prevention and Preparedness

By Commentary, In the News, UCI MIND

Dear friends of UCI MIND, Last week, Maria Shriver and the Governor’s Task Force on Alzheimer’s Prevention and Preparedness presented a report describing their 10 recommendations to Governor Gavin Newsom. Click here to view the report. The Governor was extremely receptive to the recommendations. We anticipate movement in the coming months to years on these important initiatives to improve the lives of Californians living with dementia and their families and to increase Alzheimer’s awareness, risk reduction education, and research. We would like to thank the many UCI MIND stakeholders who participated in the Task Force listening session as part of…

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Holidays during COVID-19

By Clinical Trials, Commentary, COVID-19, Longitudinal Cohort, Participants, UCI MIND

Have you noticed the Holiday decorations popping up at shopping malls already? Yes, the Holiday Season is upon us. This year, due to the COVID-19 pandemic, we all need to carefully plan our social gatherings, meals, and guests in our homes. Hopefully, you will find some helpful hints here so you can safely navigate all the Holidays you will celebrate this year.   The very best gift you can give yourself, your loved ones and your friends is to make sure you get your flu vaccine as soon as possible. Keep in mind that grocery stores and malls will be getting…

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Cartographers of the brain

By Carousel Slider, Commentary, In the News, UCI MIND

Contributed by UCI News: UCI’s Center for Neural Circuit Mapping is redrawing our understanding of mechanisms underlying several common disorders by Ian Anzlowar, UCI | November 18, 2020 Thanks to Xiangmin Xu and his team at the UCI School of Medicine’s Center for Neural Circuit Mapping, lazy eye, Alzheimer’s and other neurological diseases could become a thing of the past. Opened earlier this year, the unit focuses on basic neuroscience research, advancing knowledge of the brain by defining mechanisms and pathways that underlie neurodevelopmental, neuropsychiatric and neurodegenerative disorders. “Our 30 to 40 investigators can join forces to tackle large-scale research…

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Deep Sleep Protects Against Alzheimer’s Disease, Growing Evidence Shows

By Commentary, UCI MIND

Commentary on NPR article, contributed by Bryce Mander, PhD Numerous studies now show that multiple forms of sleep disturbance increase risk for developing dementia. Emerging work continues to demonstrate that the way in which the brain expresses sleep may be tied to how much Alzheimer’s disease (AD) pathology there is in the brain even prior to AD symptom onset. Both sleep restriction and suppression of high amplitude, low frequency brain waves – called slow waves – during deep sleep increase beta amyloid and tau, the two hallmark pathologies of AD. It is unknown how this occurs, though there is evidence of two potential mechanisms: increased production of AD…

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UCI C2C Registry now live in multiple languages

By Commentary, In the News, UCI MIND

In 2016, UCI MIND launched a local recruitment registry – the UCI Consent-to-Contact (C2C) Registry – to raise awareness of research participation opportunities at UCI (c2c.uci.edu). We are excited to announce that this fall, the UCI C2C went live in Spanish, Korean, Chinese, and Vietnamese to allow more people to access this online tool. Together with our diverse community, we will improve our understanding of Alzheimer’s disease and related dementias in diverse populations and find solutions for people of all backgrounds. To learn more about enrolling in C2C, visit c2c.uci.edu > To read more in our latest newsletter, click here >

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MIND Matters | Quarterly Newsletter | Fall 2020

By Clinical Trials, Commentary, Community Events, COVID-19, In the News, Longitudinal Cohort, Participants, UCI MIND

Message from the Director   Dear Friends of UCI MIND, As the COVID-19 pandemic continues to impact our lives this fall, the fight to solve Alzheimer’s disease and related dementias (ADRD) must charge forward. This November, the U.S. FDA will convene an advisory committee to assess potential approval of Biogen’s aducanumab, a monoclonal antibody in development for treatment of early AD. We will watch closely as aducanumab could be the first new approved drug for AD since 2005. Regardless of the outcome of the meeting and subsequent FDA decision – anticipated in March 2021 – this represents a milestone for…

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